HullC+RegehrWG-2012

Notes about [HullC+RegehrWG-2012] 1.

1

Court Hull and Wade G. Regehr. Identification of an Inhibitory Circuit that Regulates Cerebellar Golgi Cell Activity. Neuron, 73(1):149–158, January 2012. URL: https://linkinghub.elsevier.com/retrieve/pii/S0896627311009949, doi:10.1016/j.neuron.2011.10.030, Notes: HullC+RegehrWG-2012.html (this file).

This paper shows that Molecular Layer Interneurons do not inhibit Golgi cells and that Golgi cells inhibit each other through synaptic inhibition.

From abstract:

In contrast to current thought, we find that Golgi cells, not MLIs, make inhibitory GABAergic synapses onto other Golgi cells. As a result, MLI feedback does not regulate the Golgi cell network, and Golgi cells are inhibited approximately 2 ms before Purkinje cells, following a mossy fiber input. Hence, Golgi cells and Purkinje cells receive unique sources of inhibition and can differentially process shared granule cell inputs.

Fig 8. from HullC+RegehrWG-2012
Fig 8. from HullC+RegehrWG-2012

Figure 8 in HullC+RegehrWG-2012 [HullC+RegehrWG-2012].